Evaluating [²²⁵Ac]Ac-FAPI-46 for the treatment of soft-tissue sarcoma in mice.

ABSTRACT:

Purpose

Fibroblast Activation Protein (FAP) is an emerging theranostic target that is highly expressed on cancer-associated fibroblasts and on certain tumor cells including sarcoma. We investigated the anti-tumor efficacy of [²²⁵Ac]Ac-FAPI-46 as monotherapy or in combination with immune checkpoint blockade (ICB) in immunocompetent murine models of sarcoma sensitive or resistant to ICB.

Methods

[⁶⁸Ga]Ga- and [²²⁵Ac]Ac-FAPI-46 were tested in subcutaneous FAP+ FSA fibrosarcoma bearing C3H/Sed/Kam mice. The efficacy of up to three cycles of 60 kBq [²²⁵Ac]Ac-FAPI-46 was evaluated as monotherapy and in combination with an anti-PD-1 antibody. Efficacy of [²²⁵Ac]Ac-FAPI-46 and/or ICB was further compared in FAP-overexpressing FS

SUBMITTER: Taddio MF 

PROVIDER: S-EPMC11527918 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature