Whole-body parametric mapping of tumour perfusion in metastatic prostate cancer using long axial field-of-view [¹⁵O]H₂O PET.

ABSTRACT:

Purpose

Tumour perfusion is a nutrient-agnostic biomarker for cancer metabolic rate. Use of tumour perfusion for cancer growth assessment has been limited by complicated image acquisition, image analysis and limited field-of-view scanners. Long axial field-of-view (LAFOV) PET scan using [¹⁵O]H₂O, allows quantitative assessment of whole-body tumour perfusion. We created a tool for automated creation of quantitative parametric whole-body tumour perfusion images in metastatic cancer.

Methods

Ten metastatic prostate cancer patients underwent dynamic LAFOV [¹⁵O]H₂O PET (Siemens, Quadra) followed by [¹⁸F]PSMA-1007 PET. Perfusion was measured as [¹⁵O]H₂O K₁ (mL/min/mL) with a single-tissue compa

SUBMITTER: Jochumsen MR 

PROVIDER: S-EPMC11527927 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature