Changes in bone density and microarchitecture in adolescents undergoing a first kidney transplantation: a prospective study.

ABSTRACT:

Purpose

Mineral bone disorder associated with chronic kidney disease (CKD-MBD) frequently persists after kidney transplantation (KTx), being due to pre-existing CKD-MBD, immunosuppressive therapies, and post-KTx hypophosphatemia. This study aimed to evaluate bone biomarkers and microarchitecture using high resolution peripheral quantitative computed tomography (HR-pQCT) at the time of KTx and 6 months thereafter and to compare these results with those of matched healthy controls (HC).

Methods

This study presented the single-center subgroup of patients aged between 10 and 18 years included in the prospective "Bone Microarchitecture in the Transplant Patient" study (TRANSOS-NCT02729142). Patients undergoing a first KTx were matched (1:2) with HC from the "Vitamin D, Bones, Nut

SUBMITTER: De Mul A 

PROVIDER: S-EPMC11527940 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature