Mapping computational cognitive profiles of aging to dissociable brain and sociodemographic factors.

ABSTRACT: Aging is associated with declines in cognition and brain structural integrity. However, there is equivocality over (1) the specificity of affected domains in different people, (2) the location of associated patterns of brain structural deterioration, and (3) the sociodemographic factors contributing to 'unhealthy' cognition. We aimed to identify cognitive profiles displayed by older adults and determine brain and sociodemographic features potentially shaping these profiles. A sample of Southeast-Asian older adults (N = 386) participated in a multi-session study comprising cognitive testing, neuroimaging, and a structured interview. We used computational models to extract latent mechanisms underlying cognitive flexibility and response inhibition. Data-driven methods were used to construct c

SUBMITTER: Marzuki AA 

PROVIDER: S-EPMC11527976 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature