Intersecting social and environmental determinants of multidrug-resistant urinary tract infections in East Africa beyond antibiotic use.

ABSTRACT: The global health crisis of antibacterial resistance (ABR) poses a particular threat in low-resource settings like East Africa. Interventions for ABR typically target antibiotic use, overlooking the wider set of factors which drive vulnerability and behaviours. In this cross-sectional study, we investigated the joint contribution of behavioural, environmental, socioeconomic, and demographic factors associated with higher risk of multi-drug resistant urinary tract infections (MDR UTIs) in Kenya, Tanzania, and Uganda. We sampled outpatients with UTI symptoms in healthcare facilities and linked their microbiology data with patient, household and community level data. Using bivariate statistics and Bayesian profile regression on a sample of 1610 individuals, we show that individuals with highe

SUBMITTER: Keenan K 

PROVIDER: S-EPMC11528027 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature