LINC00342 regulates the PI3K-AKT signaling pathway via the miR-149-5p/FGF11 axis and affects the progression of oral cancer.

ABSTRACT:

Background

A large number of long non-coding RNAs (lncRNAs) have been implicated in the progression of oral cancer (OC). This study aimed to investigate the role of a novel lncRNA, LINC00342, in OC and elucidate its molecular mechanism.

Methods

Differential expression of lncRNA/miRNA/mRNA was analyzed using the Gene Expression Omnibus database and validated with RT-qPCR. Additionally, the expression levels of these molecules in OC cells and their effects on cell viability and cell cycle were assessed using the Cell Counting Kit-8 and flow cytometry. RNA bindings was analyzed by dual luciferase, and Western blot was used to detect the activation of relevant pathways.

Results

This study showed that, in contrast to miR-149-5p, the expression of LINC00342 and fibroblast g

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11528089 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature