Naturally derived 3-aminoquinuclidine salts as new promising therapeutic agents.

ABSTRACT: Quaternary ammonium compounds (QACs) are a biologically active group of chemicals with a wide range of different applications. Due to their strong antibacterial properties and broad spectrum of activity, they are commonly used as ingredients in antiseptics and disinfectants. In recent years, the spread of bacterial resistance to QACs, exacerbated by the spread of infectious diseases, has seriously threatened public health and endangered human lives. Recent trends in this field have suggested the development of a new generation of QACs, in parallel with the study of bacterial resistance mechanisms. In this work, we present a new series of quaternary 3-substituted quinuclidine compounds that exhibit potent activity across clinically relevant bacterial strains. Most of the derivatives had min

SUBMITTER: Crncevic D 

PROVIDER: S-EPMC11528103 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature