Personalized bioceramic grafts for craniomaxillofacial bone regeneration.

ABSTRACT: The reconstruction of craniomaxillofacial bone defects remains clinically challenging. To date, autogenous grafts are considered the gold standard but present critical drawbacks. These shortcomings have driven recent research on craniomaxillofacial bone reconstruction to focus on synthetic grafts with distinct materials and fabrication techniques. Among the various fabrication methods, additive manufacturing (AM) has shown significant clinical potential. AM technologies build three-dimensional (3D) objects with personalized geometry customizable from a computer-aided design. These layer-by-layer 3D biomaterial structures can support bone formation by guiding cell migration/proliferation, osteogenesis, and angiogenesis. Additionally, these structures can be engineered to degrade concomitant

SUBMITTER: de Carvalho ABG 

PROVIDER: S-EPMC11528123 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature