Proteomic study of medicinal mushroom extracts reveals antitumor mechanisms in an advanced colon cancer animal model via ribosomal biogenesis, translation, and metabolic pathways.

ABSTRACT:

Introduction

Colorectal cancer ranks as the third most common cancer in both men and women, with approximately 35% of cases being stage IV metastatic at diagnosis. Even with treatment advancements, the survival rates for these patients remain suboptimal. There is a significant focus on developing multi-targeted therapies due to the common issue of drug resistance in standard and targeted cancer treatments. Medicinal mushrooms, both as single compounds and as complex extracts, have undergone extensive research. Numerous types of mushrooms have been shown to be safe, effective inhibitors of cancer pathways and strong enhancers of the immune system.

Methods

In this study, we performed both qualitative and quantitative proteomic analyses using tandem mass tags (TMT) on CT26 wild

SUBMITTER: Jakopovic B 

PROVIDER: S-EPMC11528127 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature