Low-Magnitude Mechanical Signals to Preserve Skeletal Health in Female Adolescents With Anorexia Nervosa: A Randomized Clinical Trial.

ABSTRACT:

Importance

Malnourished adolescents and young adults with anorexia nervosa (AN) are at high risk for skeletal deficits.

Objective

To examine whether low-magnitude mechanical signals (LMMS) could preserve bone mineral density (BMD) throughout 6 months in adolescents and young adults with AN.

Design, setting, and participants

This double-blind, sham-controlled randomized clinical trial, conducted in a hospital-based specialty clinic, assessed female adolescents and young women without medical comorbidity or medication use that would compromise bone health. A total of 837 female adolescents were screened from January 1, 2012, to December 31, 2019, of whom 317 met the study criteria. Data analysis was performed from 2020 to 2024.

Intervention

Platform delivering lo

SUBMITTER: DiVasta AD 

PROVIDER: S-EPMC11528308 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature