Awake rabbit model of ischemic spinal cord injury with delayed paraplegia: The role of ambient temperature.

ABSTRACT:

Background

Paraplegia after spinal cord ischemia is a devastating condition in the clinic. Here, we develop an awake rabbit model of spinal cord ischemia with delayed paraplegia and explore the influence of ambient temperature on the outcomes after injury.

Methods

A total of 47 male rabbits were involved in the present study. Transient spinal cord ischemia was induced by occluding the infrarenal abdominal aorta of awake rabbits at different ambient temperatures. To find the optimal conditions for developing delayed paraplegia, hindlimb motor function after ischemia was evaluated between experiments.

Results

The onset and magnitude of ischemic injury varied with the ambient temperature maintained during the peri-ischemia period. More serious spinal cord injury occurred

SUBMITTER: Yang W 

PROVIDER: S-EPMC11528386 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature