Adipose-derived mesenchymal stem cell-incorporated PLLA porous microspheres for cartilage regeneration.

ABSTRACT:

Background

In facial plastic surgery, patients with nasal deformity are often treated by rib cartilage transplantation. In recent years, cartilage tissue engineering has developed as an alternative to complex surgery for patients with minor nasal defects via injection of nasal filler material. In this study, we prepared an injectable nasal filler material containing poly-L-lactic acid (PLLA) porous microspheres (PMs), hyaluronic acid (HA) and adipose-derived mesenchymal stem cells (ADMSCs).

Methods

We seeded ADMSCs into as-prepared PLLA PMs using our newly invented centrifugation perfusion technique. Then, HA was mixed with ADMSC-incorporated PLLA PMs to form a hydrophilic and injectable cell delivery system (ADMSC-incorporated PMH).

Results

We evaluated the biocompat

SUBMITTER: Gao C 

PROVIDER: S-EPMC11528392 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature