Aurora B facilitates cholangiocarcinoma progression by stabilizing c-Myc.

ABSTRACT:

Background

Cholangiocarcinoma (CCA), a malignancy that arises from biliary epithelial cells, has a dismal prognosis, and few targeted therapies are available. Aurora B, a key mitotic regulator, has been reported to be involved in the progression of various tumors, yet its role in CCA is still unclarified.

Methods

Human CCA tissues and murine spontaneous CCA models were used to assess Aurora B expression in CCA. A loss-of-function model was constructed in CCA cells to determine the role of Aurora B in CCA progression. Subcutaneous and liver orthotopic xenograft models were used to assess the therapeutic potential of Aurora B inhibitors in CCA.

Results

In murine spontaneous CCA models, Aurora B was significantly upregulated. Elevated Aurora B expression was also observe

SUBMITTER: Liu K 

PROVIDER: S-EPMC11528393 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature