Ni-Catalyzed Asymmetric Reductive Arylation of α-Substituted Imides.

ABSTRACT: α-Aryl imides are common structural motifs in bioactive molecules and proteolysis-targeting chimeras designed for targeted protein degradation. An asymmetric Ni-catalyzed reductive cross-coupling of imide electrophiles and (hetero)aryl halides has been developed to synthesize enantioenriched α-arylglutarimides from simple starting materials. Judicious selection of electrophile pairs allows for coupling of both electron-rich and electron-deficient (hetero)aryl halides in good yields and enantioselectivities.

SUBMITTER: Chen LM 

PROVIDER: S-EPMC11528402 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature