Harnessing Competitive Interactions to Regulate Supramolecular "Micelle-Droplet-Fiber" Transition and Reversibility in Water.

ABSTRACT: The supramolecular assembly of proteins into irreversible fibrils is often associated with diseases in which aberrant phase transitions occur. Due to the complexity of biological systems and their surrounding environments, the mechanism underlying phase separation-mediated supramolecular assembly is poorly understood, making the reversal of so-called irreversible fibrillization a significant challenge. Therefore, it is crucial to develop simple model systems that provide insights into the mechanistic process of monomers to phase-separated droplets and ordered supramolecular assemblies. Such models can help in investigating strategies to either reverse or modulate these states. Herein, we present a simple synthetic model system composed of three components, including a benzene-1,3,5-tricarb

SUBMITTER: Duijs H 

PROVIDER: S-EPMC11528417 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature