A rapid and scalable method for visible light induced bromination of uracil derivatives in a falling film looping photoreactor.

ABSTRACT: Visible light induced green synthesis of 5-bromouracil derivatives using N-bromosuccinimide (NBS) in acetonitrile under batch operation with a constant photon flux of 46 μmol s^-1 is reported. This methodology has shown excellent tolerance with various 6-substituted and N-substituted uracils and is also applicable for various pyrimidine and arene derivatives. The reaction proceeded through the formation of a bromine molecule via a radical pathway followed by an electrophilic substitution reaction, and this hybrid nature of the reaction pathway in the presence of light made the process faster. We successfully synthesized twenty-one derivatives and characterized them using various spectroscopic methods. Finally, the three different modules of the looping fallin

SUBMITTER: Naskar S 

PROVIDER: S-EPMC11528420 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature