Decarboxylative Cross-Coupling Enabled by Fe and Ni Metallaphotoredox Catalysis.

ABSTRACT: Decarboxylative cross-coupling of carboxylic acids and aryl halides has become a key transformation in organic synthesis to form C(sp²)-C(sp³) bonds. In this report, a base metal pairing between Fe and Ni has been developed with complementary reactivity to the well-established Ir and Ni metallaphotoredox reactions. Utilizing an inexpensive FeCl₃ cocatalyst along with a pyridine carboxamidine Ni catalyst, a range of aryl iodides can be preferentially coupled to carboxylic acids over boronic acid esters, triflates, chlorides, and even bromides in high yields. Additionally, carboxylic acid derivatives containing heterocycles, N-protected amino acids, and protic functionality can be coupled in 23-96% yield with a range of sterically hindered, electron-ri

SUBMITTER: Nsouli R 

PROVIDER: S-EPMC11528444 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature