Ethyl Acetate Extract from Romdoul (<i>Sphaerocoryne affinis</i>) Fruit Induced Apoptosis in Human Promyelocytic Leukemia Cells.

ABSTRACT:

Background

Romdoul (Sphaerocoryne affinis) is a flowering plant of the Annonaceae family and has been used customarily in folk medicine. The bioactivities of this plant, especially the anti-cancer effect, however, remain surprisingly few.

Objective

this study aimed to elucidate the anti-leukemic effect of romdoul fruit extracts and their underlining mechanisms.

Methods

The extracts were prepared from fresh fruits and the phytochemical contents were evaluated by biochemical assays and HPLC method. The promising extract was identified via the inhibition of HL60 as well as normal NIH-3T3 cell densities utilizing MTT assay. The underline mechanism of the extract's effect was studied by accessing the treated HL60 cell population overtime (via MTT assay). The morphol

SUBMITTER: Hoai Nga NT 

PROVIDER: S-EPMC11528603 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature