Advances in antibacterial agents for Mycobacterium fortuitum.

ABSTRACT: Mycobacterium fortuitum is an emerging human pathogen, characterized by an increase in prevalence and antibacterial resistance over the years, highlighting the need for the development of new drugs against this rapidly growing nontuberculous mycobacterium (NTM). To support this crusade, this review summarizes findings from the past two decades concerning compounds with antimycobacterial activity against M. fortuitum. It identifies the most promising and effective chemical frameworks to inspire the development of new therapeutic alternatives for infections caused by this microorganism. Most compounds effective against M. fortuitum are synthetic, with macozinone, featuring a 2-piperazine-benzothiazinone framework, standing out as a notable drug candidate. Among natural p

SUBMITTER: Roberto Tavolari Jortieke C 

PROVIDER: S-EPMC11528911 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature