Enhanced versus standard hydration in acute ischemic stroke: REVIVE-A randomized clinical trial.

ABSTRACT:

Rationale

Early neurological deterioration (END) within 72 h of stroke onset is associated with poor prognosis. Optimizing hydration might reduce the risk of END.

Aims

This study aimed to determine in acute ischemic stroke patients if enhanced hydration versus standard hydration reduced the incidence of major (primary) and minor (secondary) END, as well as whether it increased the incidence of early neurological improvement (secondary), at 72 h after admission.

Sample size estimate

A total of 244 participants per arm.

Methods and design

A prospective, double-blinded, multicenter, parallel-group, randomized controlled trial conducted at four hospitals from April 2014 to July 2020, with data analyzed in August 2020. The sample size estimated was 488 participants

SUBMITTER: Lin LC 

PROVIDER: S-EPMC11528967 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature