The Four Core Genotypes mouse model: evaluating the impact of a recently discovered translocation.

ABSTRACT: The Four Core Genotypes (FCG) mouse model has become a valuable model to study the mechanistic basis for biological sex differences. This model allows discrimination between influences of gonadal sex (ovaries or testes) from those associated with genetic sex (presence of XX or XY chromosome complement). FCG mice have illuminated distinct effects of gonadal and chromosomal sex on traits ranging from brain structure and behavior to vulnerability to obesity, atherosclerosis, multiple sclerosis, Alzheimer's and other diseases. A recent study determined that the Y^Sry- chromosome used in a specific line of C57BL/6J FCG mice harbors nine genes that have been duplicated from the X chromosome. This report raised concern that scores of publications that previously used the FCG model may t

SUBMITTER: Wiese CB 

PROVIDER: S-EPMC11529163 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature