The gut microbiome in patients with Cushing's disease affects depression- and anxiety-like behavior in mice.

ABSTRACT:

Background

Depression and anxiety significantly impact the quality of life in individuals with Cushing's disease (CD), which originates from pituitary neuroendocrine tumors (PitNETs), yet our understanding of the underlying mechanisms is limited. There is substantial evidence linking gut microbes to depression, anxiety, and endocrinology.

Results

The gut bacterial phenotype of patients with Cushing's disease was significantly different from that of the control group, and when the mice were treated with fecal bacteria from these patients, both anxiety- and depression-like behavior were significantly increased. However, this effect can be alleviated by supplementing with 2-(14, 15-epoxyeicosatrienoyl) glycerol (2-14,15-EG) which was found at reduced levels in the peripheral bl

SUBMITTER: Nie D 

PROVIDER: S-EPMC11529176 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature