Vaginal microbiota in term pregnant women with differences in cervical ripeness revealed by 2bRAD-M.

ABSTRACT:

Background

Cervical ripening is a multifactorial outcome, and the association between cervical ripening and vaginal microbiota remains unexplored in term primiparous women. A new sequencing technology, microbiome 2bRAD sequencing (2bRAD-M) that provides a higher level of species discrimination compared to amplicon sequencing. We applied 2bRAD-M to analyze the vaginal microbiota in a population with variations in cervical ripeness and to explore potential microbiota factors influencing cervical ripening.

Methods

A total of 30 full-term primigravid women participated in this study, with 15 belonging to the low scoring group of cervical ripeness and 15 to the high scoring group. Clinical information was collected from the participants, and the vaginal microbiota and community s

SUBMITTER: Lu S 

PROVIDER: S-EPMC11529209 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature