Correlation of biochemical markers and inflammatory cytokines in autism spectrum disorder (ASD).

ABSTRACT:

Introduction

Autism Spectrum Disorder (ASD) is a disorder that severely affects neurodevelopment, and its underlying causes are not yet entirely understood. Research suggests that there may be a connection between the occurrence of ASD and changes in immune responses. This study aims to know if some biochemical and inflammatory cytokines are promising biomarkers for ASD and whether they are involved in the pathogenesis of ASD.

Methods

The serum levels of CRP, TNF-α, TGF-β, IL-1β, IL-10, 1 L-8, and IL-6 were measured in all of the patients (n = 22) and in the healthy (n = 12) children using ELISA method.

Results

The serum concentrations of IL-10 and IL-8 were significantly lower in the ASD patients compared to the control group (p < 0.05) and there were not significant

SUBMITTER: Noori AS 

PROVIDER: S-EPMC11529241 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature