Sex-specific risk factors and clinical dementia outcomes for white matter hyperintensities in a large South Korean cohort.

ABSTRACT:

Objective

White matter hyperintensities (WMH) on brain MRI images are the most common feature of cerebral small vessel disease (CSVD). Studies have yielded divergent findings on the modifiable risk factors for WMH and WMH's impact on cognitive decline. Mounting evidence suggests sex differences in WMH burden and subsequent effects on cognition. Thus, we aimed to identify sex-specific modifiable risk factors for WMH. We then explored whether there were sex-specific associations of WMH to longitudinal clinical dementia outcomes.

Methods

Participants aged 49-89 years were recruited at memory clinics and underwent a T2-weighted fluid-attenuated inversion recovery (FLAIR) 3T MRI scan to measure WMH volume. Participants were then recruited for two additional follow-up visits, 1-2

SUBMITTER: Schweitzer N 

PROVIDER: S-EPMC11529246 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature