Citrus supplementation in subjective cognitive decline: results of a 36-week, randomized, placebo-controlled trial.

ABSTRACT:

Background

Developing interventions for older adults with subjective cognitive decline (SCD) has the potential to prevent dementia in this at-risk group. Preclinical models indicate that Citrus-derived phytochemicals could benefit cognition and inflammatory processes, but results from clinical trials are still preliminary. The aim of this study is to determine the effects of long-term supplementation with Citrus peel extract on cognitive performance and inflammation in individuals with SCD.

Methods

Eighty participants were randomly assigned to active treatment (400 mg of Citrus peel extract containing 3.0 mg of naringenin and 0.1 mg of auraptene) or placebo at 1:1 ratio for 36 weeks. The primary endpoint was the change in the Repeatable Battery for the Assessment of Neuropsy

SUBMITTER: Galluzzi S 

PROVIDER: S-EPMC11529263 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature