Latent factors underlying the symptoms of adult-onset myotonic dystrophy type 1 during the clinical course.

ABSTRACT:

Background

Myotonic dystrophy type 1 (DM1) is a multisystem genetic disorder that classically presents with symptoms associated with myotonia, early onset cataracts, and muscular weakness, although the presentation and pattern of disease progression is quite varied. Presenting symptoms are well documented among adults with DM1. However, less is known about the co-occurrence of symptoms over time. We aimed to use factor analysis to explore the correlation pattern of signs and symptoms (S/S) that emerged during the clinical course.

Results

Clinical records of 228 individuals with adult onset DM1 were abstracted using the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet) from a six-site cohort in the United States during an eight-year study period. Fa

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11529289 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature