Sex differences in contextual fear conditioning and extinction after acute and chronic nicotine treatment.

ABSTRACT:

Background

Chronic cigarette smokers report withdrawal symptomology, including affective dysfunction and cognitive deficits. While there are studies demonstrating sex specific withdrawal symptomology in nicotine-dependent individuals, literature examining the underlying biological mediators of this is scant and not in complete agreement. Therefore, in this study, we evaluated the sex specific effects of nicotine and withdrawal on contextual fear memory, a hippocampally dependent aspect of cognition that is disrupted in nicotine withdrawal.

Methods

Male and female B6/129F1 mice (8-13 weeks old) were used in all experiments. For the acute nicotine experiment, mice received intraperitoneal saline or nicotine (0.5 mg/kg) prior to contextual fear conditioning and test. For the ch

SUBMITTER: Keady JV 

PROVIDER: S-EPMC11529327 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature