Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma.

ABSTRACT:

Objective

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumour thought to arise from ductal cells via pancreatic intraepithelial neoplasia (PanIN) precursor lesions. Modelling of different genetic events in mice suggests both ductal and acinar cells can give rise to PDAC. However, the impact of cellular context alone on tumour development and phenotype is unknown.

Design

We examined the contribution of cellular origin to PDAC development by inducing PDAC-associated mutations, Kras^G12D expression and Trp53 loss, specifically in ductal cells (Sox9CreER;Kras^LSL-G12D;Trp53^flox/flox ('Duct:KP^cKO ')) or acinar cells (Ptf1a^CreER;Kras^LSL-G12D;Trp53^flox/flox ('

SUBMITTER: Lee AYL 

PROVIDER: S-EPMC11529381 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature