Hyperpolarised [2-¹³C]-pyruvate by ¹³C SABRE in an acetone/water mixture.

ABSTRACT: Signal Amplification By Reversible Exchange (SABRE) can provide strong signal enhancement (SE) to an array of molecules through reversible exchange of parahydrogen (pH₂) derived hydrides and a suitable substrate coordinated to a transition metal. Among the substrates that can be used as a probe for hyperpolarised NMR and MRI, pyruvate has gained much attention. SABRE can hyperpolarise pyruvate in a low cost, fast, and reversible fashion that does not involve technologically demanding equipment. Most SABRE polarization studies have been done using methanol-d₄ as a solvent, which is not suitable for in vivo application. The main goal of this work was to obtain hyperpolarized pyruvate in a solvent other than methanol which may open the door to further purification

SUBMITTER: Bondar OA 

PROVIDER: S-EPMC11529384 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature