Senolytic treatment diminishes microglia and decreases severity of experimental autoimmune encephalomyelitis.

ABSTRACT:

Background

The role of senescence in disease contexts is complex, however there is considerable evidence that depletion of senescent cells improves outcomes in a variety of contexts particularly related to aging, cognition, and neurodegeneration. Much research has shown previously that inflammation can promote cellular senescence. Microglia are a central nervous system innate immune cell that undergo senescence with aging and during neurodegeneration. The contribution of senescent microglia to multiple sclerosis, an inflammatory neurodegenerative disease, is not clear, but microglia are strongly implicated in chronic active lesion pathology, tissue injury, and disease progression. Drugs that could specifically eliminate dysregulated microglia in multiple sclerosis are therefore of

SUBMITTER: Drake SS 

PROVIDER: S-EPMC11529445 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature