Protective effect of Huashi Baidu formula against AKI and active ingredients that target SphK1 and PAI-1.

ABSTRACT:

Background

Huashi Baidu Formula (HBF) is a clinical formula known for its efficacy against coronavirus disease 2019 (COVID-19). HBF may reduce the number of patients with abnormal serum creatinine while improving respiratory symptoms, suggesting that this formula may have potential for treating acute kidney injury (AKI). However, the protective effect of HBF on AKI has not been definitively confirmed, and the mechanism remains unclear. Therefore, the present study explored the renoprotective effects and molecular mechanisms of HBF and screened for its active ingredients to identify new potential applications of renoprotection by HBF.

Methods

The present study first assessed the protective effects of HBF on AKI in a DOX-induced mouse model. Then, RNA-seq and bioinformatics an

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC11529477 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature