Living systematic review and comprehensive network meta-analysis of ALS clinical trials: study protocol.

ABSTRACT:

Introduction

Amyotrophic lateral sclerosis (ALS) is a fatal neurogenerative disease with no effective treatment to date. Despite numerous clinical trials, the majority of studies have been futile in their effort to significantly alter the course of the disease. However, these studies may still provide valuable information for identifying patient subgroups and generating new hypotheses for future research. Additionally, synthesising evidence from these studies may help overcome the limitations of individual studies. Network meta-analysis may refine the assessment of efficacy in specific patient subgroups, evaluate intervention characteristics such as mode of administration or biological mechanisms of action, and rank order promising therapeutic areas of interest. Therefore, we aim t

SUBMITTER: Van Loon FT 

PROVIDER: S-EPMC11529510 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature