Antifungal combinations in paediatric invasive fungal infections: a protocol for systematic review and meta-analysis.

ABSTRACT:

Background

Invasive fungal infections (IFIs) significantly impact immunocompromised paediatric patients, contributing to high rates of morbidity and mortality. Despite the evolution of antifungal therapy, the efficacy and safety of combination antifungal therapies in paediatric patients, especially those with haematological malignancies, remain controversial. This systematic review and meta-analysis seeks to critically evaluate the efficacy and safety of antifungal combinations in paediatric IFIs.

Methods

We will conduct a search in PubMed, ScienceDirect, Cochrane Library, BMJ and Springer databases to include randomised controlled trials and observational studies focused on combination antifungal therapies in paediatric patients under 18 years with IFIs, using COVIDENCE for

SUBMITTER: Ramadhan RN 

PROVIDER: S-EPMC11529516 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature