Analytical modelling techniques for enhancing tacrolimus dosing in solid organ transplantation: a systematic review protocol.

ABSTRACT:

Introduction

Tacrolimus is an immunosuppressant commonly administered in transplant recipients. Given its narrow therapeutic range and susceptibility to various influencing variables, determining its optimal dosage is challenging. This systematic review seeks to identify effective analytical modelling techniques and methods for optimal tacrolimus dose prediction in solid transplant recipients.

Methods and analysis

This review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. The study will review the literature published from database inception to 11 March 2024, that assesses predictive models of tacrolimus dosing through analytical modelling techniques. We will include both randomised and non-randomised, as well as cross-s

SUBMITTER: Amooei E 

PROVIDER: S-EPMC11529584 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature