Grading carcinoembryonic antigen levels can enhance the effectiveness of prognostic stratification in patients with colorectal cancer: a single-centre retrospective study.

ABSTRACT:

Objectives

This study developed a refined carcinoembryonic antigen (CEA) grading system using CEA cut-off points of 5, 20 and 50 ng/mL and to explore the prognostic value of CEA grading in predicting the progression-free survival (PFS) and overall survival (OS) of colorectal cancer (CRC) patients.

Design

A retrospective cohort study.

Setting

First Affiliated Hospital of Guangxi Medical University.

Participants

1107 CRC patients who received surgical treatment.

Materials and methods

Survival analysis was conducted using the Kaplan-Meier method and compared using the log-rank test. A Cox regression model with a 95% CI was used to evaluate the independent prognostic risk factors for CRC. Prognostic nomograms were constructed to predict the 1-5-year PFS/OS.<

SUBMITTER: Xie H 

PROVIDER: S-EPMC11529588 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature