In-depth study of pyroptosis-related genes and immune infiltration in colon cancer.

ABSTRACT:

Background

Pyroptosis is a form of regulated necrosis that occurs in many cell and tissue types and plays a critical role in tumor progression. The diagnostic value of pyroptosis-related genes (PRGs) in colon cancer has been widely investigated. In the present study, we explored the relationship between PRG expression and colon cancer.

Methods

We retrieved genomic and clinical data pertaining to The Cancer Genome Atlas-Colon Adenocarcinoma from the UCSC Xena database, along with the corresponding genome annotation information from the GENCODE data portal. Utilising these data and a list of 33 pyrogenic genes, we performed principal component analysis and unsupervised clustering analysis to assess the pyroptosis subtypes. We analysed the differential expression between these

SUBMITTER: Shang B 

PROVIDER: S-EPMC11529595 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature