A gravity-driven tissue chip to study the efficacy and toxicity of cancer therapeutics.

ABSTRACT: Tissue chip and organs-on-chip technologies have emerged as promising tools in preclinical studies. In oncology, this is driven by the high failure rates of candidate drugs in clinical trials mainly due to inadequate efficacy or intolerable toxicity and the need for better predictive preclinical models than those traditionally used. However, the intricate design, fabrication, operation, and limited compatibility with automation limit the utility of tissue chips. To tackle these issues, we designed a novel 32-unit tissue chip in the format of standard 96-well plates to streamline automation, fabricated it using 3D printing, and leveraged gravity-driven flow to bypass the need for external flow devices. Each unit includes three interconnected tissue compartments that model liver, tumor, and

SUBMITTER: Rafsanjani Nejad P 

PROVIDER: S-EPMC11529822 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature