Spatial Cellular Networks from omics data with SpaCeNet.

ABSTRACT: Advances in omics technologies have allowed spatially resolved molecular profiling of single cells, providing a window not only into the diversity and distribution of cell types within a tissue, but also into the effects of interactions between cells in shaping the transcriptional landscape. Cells send chemical and mechanical signals which are received by other cells, where they can subsequently initiate context-specific gene regulatory responses. These interactions and their responses shape the individual molecular phenotype of a cell in a given microenvironment. RNAs or proteins measured in individual cells, together with the cells' spatial distribution, provide invaluable information about these mechanisms and the regulation of genes beyond processes occurring independently in each indi

SUBMITTER: Schrod S 

PROVIDER: S-EPMC11529864 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature