Mathematical modeling of vancomycin release from Poly-L-Lactic Acid-Coated implants.

ABSTRACT: This study aimed to develop a mathematical model to predict the release profile and antibacterial efficacy of a vancomycin delivery system integrated with poly(L-lactic acid)-coated bone implants specifically designed for bone plates. Using Fickian diffusion principles within an ANSYS-CFX computational fluid dynamic model, we validated the model against our in vitro vancomycin release and agar diffusion studies, as well as previously published in vivo data, confirming the reliability of the model. The model predictions demonstrated the effectiveness of the system in inhibiting bacterial growth in surrounding tissue with no observed toxicity, with a peak vancomycin concentration of 0.95 mg/ml at 6 hours, followed by a decrease to levels that remained effective for antibacterial activity. Fu

SUBMITTER: Thamvasupong P 

PROVIDER: S-EPMC11530042 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature