Use of dislodgeable foliar residue studies for the evaluation of isomerization potential of active substances for non-dietary risk assessment.

ABSTRACT: When assessing the non-dietary risks for operators, workers, bystanders and residents to active substances in plant protection products (PPPs) that contain stereoisomers, the EFSA guidance on stereoisomers recommends the application of uncertainty factors when the initial ratio of stereoisomers undergoes a significant stereoisomeric excess change of more than 10%. This precautionary approach may be over-conservative in cases where the change in isomers is due to differences in their degradation rates rather than conversion of one isomer to a potentially more toxic isomer. Therefore, the impact of isomeric composition in non-dietary risk assessments of PPPs was evaluated, with particular emphasis on dislodgeable foliar residues (DFR) data and potential enantioselective degradation processes

SUBMITTER: Wagner S 

PROVIDER: S-EPMC11530052 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature