Within-subject variation of C-reactive protein and high-sensitivity C-reactive protein: A systematic review and meta-analysis.

ABSTRACT:

Background

C-reactive protein (CRP) and high-sensitivity C-reactive protein (hsCRP) are measures of inflammation used in diagnosis, to guide treatment decisions, and in disease prediction. Variability in measured CRP and hsCRP may affect their clinical utility but estimates of within-subject variability are based on limited data.

Methods

A systematic review and meta-analysis was performed to estimate longitudinal within-subject variability of CRP and hsCRP over any time period. Follow-up studies of any design in adults or children, with repeated measures of CRP or hsCRP were sought. Multiple databases were searched from inception to November 2022. Titles and abstracts were screened in duplicate. Full text screening and data extraction were performed by one reviewer and verif

SUBMITTER: Gough A 

PROVIDER: S-EPMC11530069 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature