Sleep and diurnal alternative polyadenylation sites associated with human APA-linked brain disorders.

ABSTRACT: Disruption of sleep and circadian rhythms are a comorbid feature of many pathologies, and can negatively influence many health conditions, including neurodegenerative disease, metabolic illness, cancer, and various neurological disorders. Genetic association studies linking sleep and circadian disturbances with disease susceptibility have mainly focused on changes in gene expression due to mutations, such as single-nucleotide polymorphisms. The interaction between sleep and/or circadian rhythms with the use of Alternative Polyadenylation (APA) has been largely undescribed, particularly in the context of other disorders. APA generates transcript isoforms by utilizing various polyadenylation sites (PASs) from the same gene affecting its mRNA translation, stability, localization, and subseque

SUBMITTER: Flores CC 

PROVIDER: S-EPMC11530375 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature