Altered resting-state functional connectivity in a thalamo-cortico-cerebellar network in patients with schizophrenia.

ABSTRACT: The diagnosis of schizophrenia is associated with a complex psychopathology related to disrupted brain circuitry causing a failure in coordinating information across brain sites with no consensus regarding the mechanisms. Although schizophrenia is well-studied, the great majority of studies investigated pre-selected ROIs or Seed-based connectivity. Whole brain ROI-wise studies that consider all ROIs available simultaneously are lacking. This technique helps understand large- and local-scale dynamics of information exchange across the whole brain. We investigated ROI-wise whole brain networks in 35 participants diagnosed with schizophrenia and 41 control participants. To unveil dysfunctions in brain subnetworks and to characterize network topology, we applied a statistical tool specially de

SUBMITTER: Forlim CG 

PROVIDER: S-EPMC11530429 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature