GUCA2A dysregulation as a promising biomarker for accurate diagnosis and prognosis of colorectal cancer.

ABSTRACT: Colorectal cancer is a leading cause of global mortality and presents a significant barrier to improving life expectancy. The primary objective of this study was to discern a unique differentially expressed gene (DEG) that exhibits a strong association with colorectal cancer. By achieving this goal, the research aims to contribute valuable insights to the field of translational medicine. We performed analysis of colorectal cancer microarray and the TCGA colon adenoma carcinoma (COAD) datasets to identify DEGs associated with COAD and common DEGs were selected. Furthermore, a pan-cancer analysis encompassing 33 different cancer types was performed to identify differential genes significantly expressed only in COAD. Then, comprehensively in-silico analysis including gene set enrichment analy

SUBMITTER: Jalali P 

PROVIDER: S-EPMC11530487 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature