The associations between exposure to mixed environmental endocrine disruptors and sex steroid hormones in men: a comparison of different statistical models.

ABSTRACT: In recent years, worldwide fertility rates have continued to decrease. Humans are frequently exposed to a combination of environmental endocrine disruptors, which can cause male reproductive disorders. The study employed three distinct analytical models to examine the correlation between exposure to a combination of 25 chemicals and sex steroid hormone levels in adult males. This involved evaluating 12 chemicals and their metabolites from personal care and consumer products, as well as 13 metabolites linked to phthalates and plasticisers. The study analysed 25 chemicals and 3 measured sex steroid hormone outcomes, as well as two calculated hormonal outcomes (free androgen index, TT/E2 ratio) in 1262 adult men who participated in the National Health and Nutrition Examination Survey (NHANES)

SUBMITTER: Zhao S 

PROVIDER: S-EPMC11530574 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature