Allometric fat mass index and alanine aminotransferase attenuate the associations of platelet parameters with lung cancer risk.

ABSTRACT: We have previously shown that body mass index attenuates a positive association of platelet count (PLT) and inverse of mean platelet volume (MPV) with lung cancer risk in men. It is unclear whether fat mass, lean mass, or liver function tests (LFTs) show similar attenuations. Using bioelectrical impedance measurements (UK Biobank cohort) and multivariable Cox proportional hazards models, we examined the associations of allometric fat-mass index (AFI, fat mass adjusted for height), allometric lean-mass index (ALI, fat-free mass adjusted for height and fat mass), and LFTs with lung cancer risk and their multiplicative and additive interactions with platelet parameters. Based on 1573 lung cancer cases in men and 1473 in women with body composition measurements (1541 in men; 1428 in women with

SUBMITTER: Christakoudi S 

PROVIDER: S-EPMC11530616 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature