Correlation of intratumoral mast cell quantity with psychosocial distress in patients with pancreatic cancer: the PancStress study.

ABSTRACT: Mast cells are commonly found in pancreatic ductal adenocarcinoma (PDAC), yet their role in the disease remains uncertain. Although mast cells have been associated with depression in several diseases, their connection to PDAC in this context remains unclear. This study explored the correlation between mast cells and psychosocial stress in patients with PDAC. Prior to surgery, 40 patients with PDAC (n = 29 primary resected, n = 11 neoadjuvant treated) completed four questionnaires assessing stress and quality of life. Immunostaining was performed on the resected tumor tissue. Spearman analysis was employed to correlate mast cells with distress and neuropeptides serotonin and beta-endorphin serum and tissue levels. Patients with PDAC exhibited elevated levels of distress and worry. Lower num

SUBMITTER: Sitte A 

PROVIDER: S-EPMC11530627 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature