Intravascular delivery of an ultraflexible neural electrode array for recordings of cortical spiking activity.

ABSTRACT: Although intracranial neural electrodes have significantly contributed to both fundamental research and clinical treatment of neurological diseases, their implantation requires invasive surgery to open craniotomies, which can introduce brain damage and disrupt normal brain functions. Recent emergence of endovascular neural devices offers minimally invasive approaches for neural recording and stimulation. However, existing endovascular neural devices are unable to resolve single-unit activity in large animal models or human patients, impeding a broader application as neural interfaces in clinical practice. Here, we present the ultraflexible implantable neural electrode as an intravascular device (uFINE-I) for recording brain activity at single-unit resolution. We successfully implanted uFIN

SUBMITTER: Wang X 

PROVIDER: S-EPMC11530632 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature