Association between hearing loss and gout based on National Health and Nutrition Examination Survey and Mendelian randomization analysis.

ABSTRACT: Hearing loss(HL) represents a significant public health concern. This study aimed to determine the association between hearing loss and gout and to elucidate the underlying causative mechanisms. Data for this study were obtained from the National Health and Nutrition Examination Survey (NHANES) and Mendelian randomization (MR) basic databases. Initially, baseline characteristics of individuals with and without gout were compared. A nonlinear relationship between pure tone audiometry (PTA) values and gout prevalence was confirmed through restricted cubic spline (RCS) curve analysis. Subsequently, hearing loss was categorized into different levels based on PTA values, and multiple logistic regression analysis was employed to calculate the impact of varying degrees of hearing loss on the risk

SUBMITTER: Fu X 

PROVIDER: S-EPMC11530675 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature